SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic차등 공동 발현 네트워크 분석, 코로나19 팬데믹에 대한 잠재적인 치료 표적으로 핵심 허브-높은 트래픽 유전자 밝혀Immunology Published on 2021-12-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Acute kidney injury acute lung injury ADRB2 AhR AKI Analysis analyzed approach approaches ARDS Asthma cardiovascular disease cardiovascular diseases CASP1 caused CCL5 co-expressed co-expression co-expression network analysis coagulation disorders Combination Comorbidities Comorbidity complications COVID-19 COVID-19 pandemic COVID-19 patient cytokine Cytokine storm Diabetic diabetic complications distress Factors functional enrichment Functional enrichment analysis GDI2 gene co-expression network gene expression matrix gene networks generate Genes GzmB healthy healthy sample healthy samples HIF1a highest Host Host immune response HSP90AA1 HSPA5 HSPD1 hub genes hub-high traffic genes ICAM1 identify IFNg IL10 IL1B IL6 Immunopathogenesis information IRAK3 knowledge liver disorder Liver disorders Lung injury lymphopenia MAPK1 mechanism Mild molecular molecular mechanism molecular mechanisms mononuclear cell mononuclear cells network NFkB1 OASL Pathways PBMCs Peripheral blood Peripheral blood mononuclear cells Perturbation Potential PPI Pregnancy pregnancy complications PRF1 protein-protein interaction provide PTEN RAB5A Regulatory respiratory distress Respiratory distress syndrome Result RHOA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-host interaction SARS-CoV-2-host interactions signaling pathway signaling pathways SOCS1 SOCS3 Spread SUMO1 syndrome Systems biology systems immunology target Therapeutic strategies therapeutic target therapeutic targets therapeutic targets in infectious diseases thrombosis TNF TNFRSF1A TP53 Traffic transcriptional transcriptomics transfer was used were used WGCNA with COVID-19 [DOI] 10.3389/fimmu.2021.789317 PMC 바로가기 [Article Type] Immunology
Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesisCOVID-19 발병 과정에서 취약한 숙주 단백질을 식별하기 위한 SARS-CoV-2의 숙주-바이러스 상호작용 분석Article Published on 2021-09-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, [키워드] Analysis CANX CAPZB cellular centrality complex composed COVID-19 COVID-19 pathogenesis Critical disease Diseases effort functional enrichment Functional enrichment analysis Genetic Host host protein HSPA1A HSPA5 human proteins human respiratory tract identify identifying IGF2R infection mechanism interactions involved ITCH Laboratory molecular mechanism molecular mechanisms neurodegenerative Pathogenesis Pathways performed potential therapeutic targets produced Protein protein-protein interaction Proteins PSMC5 RAB5A RAB7A RAB8A RBX1 Respiratory tract diseases SARS-CoV-2 SARS-CoV-2. Signaling therapeutic target therapeutic targets [DOI] 10.1016/j.meegid.2021.104921 PMC 바로가기 [Article Type] Article